I can remember the last department stores in Akron, OH closing in the late 70's - Polsky's and O'Neil's. Also, I expect many mid-sized US cities no longer have a downtown dept. store - Flint, Toledo, Akron, etc.

Dept. stores are high cost and require a high population living/working downtown to survive. Most of the remaining ones are selling exactly what is sold in their suburban stores, and no longer offer some things like appliances, furniture, hardware, etc. depending on the chain. At one time Detroit's Hudson's was a one-stop store that sold almost everything.