Yes, Toledo's beautiful art moderne Central Union Station is the busiest Amtrak station in Ohio, in part due to the guarenteed Amtrak Thruway bus connection to Michigan [[Detroit, Dearborn, Ann Arbor, East Lansing). Passenger usage at Toledo actually increased 8% to over 54,000 passengers in FY2009. Detroit-Cleveland was of course the route of the NYC Mercury back in the day, with Toledo being an important mid way stop on that route.

In order for a train to make sense between Toledo and Michigan, it would have to be southbound to Toledo in the late evening, to make a reasonable connection to the EB long distance routes [[Capitol Limited and Lake Shore Limited) and then northbound in the morning to bring passengers from the westbound trains up into Michigan. This could be accomplished by having eastbound train 354 turn south toward Toledo in the evening, and westbound train 353, on an earlier schedule, return northward.

The old Amtrak Lake Cities was the train that ran between Detroit and Toledo via the NYC/Conrail Detroit Line. The train had no intermediate stops and was not coordinated to work well with the long distance trains at Toledo, I don't think.