The Regis is indeed open. The area surrounding is fine - New Center is actually rather busy throughout the day, however if you need transportation downtown that could be an issue - not so sure how reliable the St Regis shuttle is. That said, I have no idea about the status inside the St Regis.

You can always try priceline. I've scored the Marriott at the RenCen for $70 several times, and the Holiday Inn Express, which is actually pretty nice, for $40 on a couple of ocassions.