What usually kills museums is optimism. They take on debt to expand/improve, and then it turns out they can't generate the income and donations needed to pay the debt service. The Science Center did a big upgrade, and they also spent a bunch of money on the Accidental Mummies exhibit which they had hoped would earn money touring, but didn't. At the same time, the economy has reduced donations all over the non-profit world.

The good news is that the museum is there. Even if it ends up getting foreclosed on, it isn't likely to be converted to a different use. Some group [[or the same group) will figure out how to get it running again.