Most of Minneapolis is pretty safe. The crime rate is much lower than Detroit's. That is a starting point because to have a successful light rail line and a downtown that is full of people even at night like Minneapolis does, there can't be much crime.
Besides Target and Best Buy, the Twin Cities are a hub of the US grain industry and home of high tech manufacturers 3M, Medtronic, and St. Jude. Target took over the J.L. Hudson company many years ago.
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