Those lots will always be prime targets for development. While there is a growing number of people who want to live downtown, it is finite, and I'd rather see areas redeveloped that fill in empty buildings or vacant lots that are actually near other locations that would benefit. As you say, that area is pretty cut off from the rest of downtown, and for that exact reason isn't critical to improve.
No doubt it will happen eventually, but I'm not in a hurry. Someone is going to have to be left to pay to live in the Fisher Building and the Book Tower.
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